https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44978 Wed 26 Oct 2022 08:53:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51831 Wed 20 Sep 2023 10:15:04 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34074 Wed 19 Jan 2022 15:19:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32668 Wed 19 Jan 2022 15:16:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36948 Wed 19 Jan 2022 15:16:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48048 Wed 13 Mar 2024 14:19:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52446 Wed 11 Oct 2023 14:54:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11265 Wed 11 Apr 2018 16:57:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11474 Wed 11 Apr 2018 16:53:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18377 Wed 11 Apr 2018 15:30:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15341 Wed 11 Apr 2018 15:01:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26012 Wed 11 Apr 2018 14:44:48 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21083 Wed 11 Apr 2018 14:39:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28903 Wed 11 Apr 2018 14:35:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14141 Wed 11 Apr 2018 14:22:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6869 Wed 11 Apr 2018 14:09:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8266 Wed 11 Apr 2018 13:36:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6942 Wed 11 Apr 2018 12:53:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15132 Wed 11 Apr 2018 12:40:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15339 Wed 11 Apr 2018 11:59:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6868 Wed 11 Apr 2018 11:47:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22606 16 years) were admitted with confirmed influenza to one of 15 of 17 FluCAN sentinel hospitals (excluding 2 paediatric hospitals). Of these, 47% were over 65 years of age, 10% were Indigenous Australians, 3.3% were pregnant and 85% had chronic co-morbidities. The majority of cases were due to influenza A. Influenza B was detected in 7% of patients. There were a large number of hospital admissions detected with confirmed influenza in this national observational surveillance system in 2014. These are estimated to represent a national annual burden of around 15,000 admissions and almost 100,000 bed-days nationally.]]> Wed 11 Apr 2018 10:29:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15153 Wed 11 Apr 2018 10:24:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23627 Wed 11 Apr 2018 10:17:52 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53717 Wed 10 Jan 2024 11:16:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53965 Wed 06 Mar 2024 15:17:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21107 Wed 04 Sep 2019 10:31:12 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52146 Wed 04 Oct 2023 10:20:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37457 Wed 02 Mar 2022 14:26:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37205 Wed 02 Mar 2022 14:25:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30212 Tue 28 Jan 2020 14:54:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48578 Tue 21 Mar 2023 17:37:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44603 Tue 18 Oct 2022 08:37:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54220 65 years of age, 36 (8%) were children (< 16 years), 6 (1%) were Aboriginal and Torres Strait Islander peoples, 4 (1%) were pregnant and 289 (65%) had chronic comorbidities. COVID-19 hospital admissions peaked between weeks 13 and 15 (first wave) nationally, and again between weeks 31 and 35 (Victoria), with most admissions represented by those above 40 years of age. Discussion: There was an unusually low number of hospital admissions with laboratory-confirmed influenza in this season, compared to recent seasons. This is likely to be due to effective public health interventions and international border closures as a result of a rise in COVID-19 respiratory infections and associated hospitalisations.]]> Tue 13 Feb 2024 12:02:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45097 Thu 27 Oct 2022 13:58:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22003 Thu 23 Aug 2018 11:26:32 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34512 Thu 17 Mar 2022 14:40:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52205 Thu 05 Oct 2023 10:15:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13980 Sat 24 Mar 2018 08:24:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16017 Sat 24 Mar 2018 08:19:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13324 Sat 24 Mar 2018 08:17:00 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10647 Sat 24 Mar 2018 08:13:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11060 Sat 24 Mar 2018 08:10:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17439 Sat 24 Mar 2018 08:01:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5105 Sat 24 Mar 2018 07:48:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6860 Sat 24 Mar 2018 07:47:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5389 Sat 24 Mar 2018 07:43:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28621 Sat 24 Mar 2018 07:38:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25897 Sat 24 Mar 2018 07:28:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27042 Sat 24 Mar 2018 07:25:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23894 Sat 24 Mar 2018 07:16:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22085 Sat 24 Mar 2018 07:15:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21998 Sat 24 Mar 2018 07:14:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38437 Mon 29 Jan 2024 18:01:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46666 Mon 28 Nov 2022 18:39:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36921 Mon 27 Jul 2020 12:48:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36574 Mon 24 Jul 2023 18:02:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32170 Mon 23 Sep 2019 13:39:38 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55279 Mon 13 May 2024 15:32:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44153 90% probability of a safety signal being detected by AusVaxSafety based on solicited reports for either fever or medical attendance at or before the week ending 28 March 2010, 3 weeks after the start of vaccine distribution. Suspension of the national paediatric influenza vaccination programme as a result of the passive adverse events surveillance operating at the time did not occur until 23 April 2010. Conclusions: Active vaccine safety surveillance leading to rapid detection of a safety signal would likely have resulted in earlier suspension of Fluvax from the vaccination programme, prevention of many febrile convulsions and maintenance of public confidence in influenza vaccination for young children.]]> Mon 10 Oct 2022 09:31:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36789 Mon 06 Jul 2020 11:38:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33077 Chlamydia, Haemophilus influenzae, influenza, and respiratory syncytial virus respiratory tract infections and ovalbumin-induced, severe, steroid-insensitive allergic airway disease (SSIAAD) in BALB/c mice were developed and interrogated. Results: Infection induced increases in the levels of microRNA (miRNA)-21 (miR-21) expression in the lung during SSIAAD, whereas expression of the miR-21 target phosphatase and tensin homolog was reduced. This was associated with an increase in levels of phosphorylated Akt, an indicator of phosphoinositide 3-kinase (PI3K) activity, and decreased nuclear histone deacetylase (HDAC)2 levels. Treatment with an miR-21-specific antagomir (Ant-21) increased phosphatase and tensin homolog levels. Treatment with Ant-21, or the pan-PI3K inhibitor LY294002, reduced PI3K activity and restored HDAC2 levels. This led to suppression of airway hyperresponsiveness and restored steroid sensitivity to allergic airway disease. These observations were replicated with SSIAAD associated with 4 different pathogens. Conclusion: We identify a previously unrecognized role for an miR-21/PI3K/HDAC2 axis in SSIAAD. Our data highlight miR-21 as a novel therapeutic target for the treatment of this form of asthma.]]> Fri 24 Aug 2018 14:41:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38008 Fri 23 Jul 2021 15:13:02 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52654 Fri 20 Oct 2023 08:55:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53863 Fri 19 Jan 2024 12:31:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40169 in vitro model of the pulmonary epithelial-endothelial barrier and novel murine models to investigate the role of glycemic variability in influenza severity. In vitro, a history of glycemic variability significantly increased influenza-driven cell death and destruction of the epithelial-endothelial barrier. In vivo, influenza virus-infected mice with a history of glycemic variability lost significantly more body weight than mice with constant blood glucose levels. This increased disease severity was associated with markers of oxidative stress and hyperinflammation both in vitr and in vivo. Together, these results provide the first indication that glycemic variability may help drive the increased risk of severe influenza in people with diabetes mellitus.]]> Fri 15 Jul 2022 10:39:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48813 Fri 14 Apr 2023 15:58:29 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46122 Fri 11 Nov 2022 15:07:57 AEDT ]]>